Proteoglycan-induced Ankylosing Spondylitis model (AS)

The pathology of ankylosing spondylitis (AS) and related spondyloarthropathies (SpA) characteristically involve a sacroiliitis and inflammation of the intervertebral discs (IVD) in the lumbar spine, and an enthesitis at sites of ligamentous insertions into bone.

  • Proteoglycan (PG) induced model / Freund adj. Induction
  • FMT / PET imaging of inflammation
  • CT imaging of bones / skeleton
  • Macroscopic eval. / scoring

Model stills on development at Imavita.
For additional informations on this model or on other preclinical models in osteo-articular pathologies, please inquire.