Imavita publications / Preclinical efficacy CROScientific background of the scientific team of Imavita (Bibliography / Publications / Scientific Communications)


Dermatology

Lacoste E., Coherent Optical Tomography Imaging of Epidermal Hyperplasia in Vivo in a Mouse Model of Oxazolone Induced Atopic Dermatitis, World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences, Vol:13, No:7, 2019 (Poster link)

A. Blanco, E. Lacoste, V. Albinet, A. Gavaldà, Murine models relevant to acne: Ear sebaceous gland and Rhino comedone models, January 2019, Journal of Comparative Pathology 166:120, DOI:10.1016/j.jcpa.2018.10.066 / Proceedings of the Joint 36th Congress of the European Society of Veterinary Pathology and 29th Congress of the European College of Veterinary Pathologists, Cluj-Napoca, Romania, 5th September – 8th September, 2018 (Poster link)

Lacoste E., Imagerie par Tomographie Optique Cohérente (OCT) in vivo chez l’animal de laboratoire : Corrélation avec l’histologie ex vivo, 31ème Congrès AFH (Association Française d’Histotechnologie), Toulouse, France, 21-22 juin 2018 (AFH 2018 program / Oral presentation available on request)

Lacoste E, Exploration of skin surface lipids in veterinary species, Proceedings European Association of Veterinary Pharmacology and Toxicology 2012 / Noordwijkerhout, The Netherlands (Poster link)


Oncology

V. Albinet, E. Lacoste, R. Baron, R. Palmantier, M. Frohlich, J.L. Dasseux, Novel Apolipoprotein-A1 (ApoA-I) multimers, Cargomer®, as new targeted delivery platform for therapeutic cancer vaccines with tumor neo- and shared-antigens, Poster board PB-100, Abstract N°149, 30th EORTC-NCI-AACR SYMPOSIUM, Dublin, Ireland, 13-16 June 2018 (Abstract link / Poster link)

V. Albinet, E. Lacoste, R. Baron, R. Palmantier, M. Frohlich, J.L. Dasseux, Pre-beta HDL discoidal mimetic, CER-001®, and novel Apolipoprotein A-I (ApoA-I) multimers, Cargomer®, as new targeted delivery vehicles for therapeutic cancer medicines, Poster board PB-024, Abstract N°263, 30th EORTC-NCI-AACR SYMPOSIUM, Dublin, Ireland, 13-16 June 2018 (Abstract link / Poster link)

Poitevin S, Cussac D, Leroyer AS, Albinet V, Sarlon-Bartoli G, Guillet B, Hubert L, Andrieu-Abadie N, Couderc B, Parini A, Dignat-George F, Sabatier F, Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. Cardiovasc Res. 2014 Jul 1;103(1):121-30  (PubMed link)

Albinet V, Bats ML, Huwiler A, Rochaix P, Chevreau C, Ségui B, Levade T, Andrieu-Abadie N. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene. 2013 Jul 29 (PubMed link)

Albinet V, Bats ML, Bedia C, Sabourdy F, Garcia V, Ségui B, Andrieu-Abadie N, Hornemann T, Levade T. Genetic disorders of simple sphingolipid metabolism. Sphingolipids: Basic Science and Drug Development, Handbook of Experimental Pharmacology Volume 215, 2013, pp 127-152 (PubMed link)

Sorli SC, Colié S, Albinet V, Bedia C, Carpentier S, Ségui B, Guilbaud N, Levade T, Andrieu-Abadie N. Non-lysosomal beta-glucosidase GBA2 as a novel source of glucosylceramide catabolism involved in the regulation of melanoma growth. FASEB J. 2013 Feb;27(2):489-98 (PubMed link)

Albinet V, Bedia C, Huwiler A, Levade T, Andrieu-Abadie N, Role of sphingolipids in melanoma-stroma interactions, Bulletin du Cancer, Oct 2010, 97(4), S18-S18 (Poster link)

Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N. Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res. 2009 Dec 15;69(24):9346-53 (PubMed link)

Autefage H, Albinet V, Garcia V, Berges H, Nicolau ML, Therville N, Altié MF, Caillaud C, Levade T, Andrieu-Abadie N. Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner. J Biol Chem. 2009 Apr 24;284(17):11507-16 (PubMed link)

Decaup E, Rochotte J, Pyronnet S, Bousquet C. Focal Adhesion Kinase: A promising therapeutic target in pancreatic adenocarcinoma. Jean C. Clin Res Hepatol Gastroenterol. 2017 Jun;41(3):246-248. doi: 10.1016/j.clinre.2016.10.010. Epub 2016 Dec 6 (PubMed link)

Bertrand F, Rochotte J, Colacios C, Montfort A, Andrieu-Abadie N, Levade T, Benoist H, Ségui B, Targeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma? Oncoimmunology. 2015 Aug 12;5(1):e1068495. eCollection 2016 (PubMed link)

Bertrand F, Rochotte J, Colacios C, Montfort A, Tilkin-Mariamé AF, Touriol C, Rochaix P, Lajoie-Mazenc I, Andrieu-Abadie N, Levade T, Benoist H, Ségui B, Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma. Cancer Res. 2015 Jul 1;75(13):2619-28. doi: 10.1158/0008-5472.CAN-14-2524. Epub 2015 May 14 (PubMed link)


Preclinical imaging

Lacoste E, Dual energy computed tomography imaging of atherosclerosis in an induced focal aortic inflammation rabbit model, Proceedings European Atherosclerosis Society 2012 / 80th EAS Congress, Milan, Italy, May 25-28th 2012
Lacoste E, Dual energy computed tomography imaging of atherosclerosis in a diet induced atheroma rabbit model, Proceedings European Atherosclerosis Society 2011 / 79th EAS Congress, Gothenburg, Sweden, June 26-29th 2011


Pharmacokinetics / Pharmacodynamics

Kovalchin J, Krieger J, Collins K, Genova M, Augustyniak M, Masci A, Avril T, Gandon G, Patat A, Fauchoux N, Toutin C, Lacoste E, Patel U, Mascioli E, Zanelli E, Safety, pharmacokinetic, and pharmacodynamic evaluations of PI-2301, a potent immunomodulator, in a first-in-human, single-ascending-dose study in healthy volunteers. J Clin Pharmacol. 2011 May;51(5):649-60 (PubMed link).

DeLay RL, Lacoste E, Mezzasalma T, Blond-Riou F, Pharmacokinetics of metaflumizone and amitraz in the plasma and hair of dogs following topical application, Vet. Parasitol., 2007, 150 (3), 251-7 (PubMed link).

DeLay RL, Lacoste E, Delprat S, Blond-Riou F, Pharmacokinetics of metaflumizone and amitraz in the plasma and hair of cats following topical application, Vet. Parasitol., 2007, 150 (3), 258-62 (PubMed link)

Alvinerie M, Lacoste E, Sutra JF, Chartier C.Some pharmacokinetic parameters of eprinomectin in goats following pour-on administration, Vet Res Commun. 1999 Nov;23(7):449-55 (PubMed link).


Neurology

Bonnard E, Poras H, Fournié-Zaluski MC, Roques BP. Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain. Eur J Pharmacol. 2016 Oct 5;788:176-182. doi: 10.1016/j.ejphar.2016.05.041. Epub 2016 Jun 4 (Pubmed link)

H. Poras, E. Bonnard, M.-C. Fournié-Zaluski, B.P. Roques. Modulation of Disulfide Dual ENKephalinase Inhibitors (DENKIs) Activity by a Transient N-protection for Pain Alleviation by Oral Route. European Journal of Medicinal Chemistry (2015), doi: 10.1016/ j.ejmech.2015.07.027 (Pubmed link)

E. Bonnard, H. Poras, X. Nadal, R. Maldonado, M.-C. Fournié-Zaluski, B. P. Roques. Long lasting oral analgesic effects of N-Protected Aminophosphinic Dual ENKephalinase Inhibitors (DENKIs) in peripherally-controlled pain. Pharma Res Per, 3(2), 2015, Mar;3(2):e00116. doi:  10.1002/prp2.116. Epub 2015 Jan 30 (Pubmed link)

Poras H, Bonnard, E. Dange, M.-C. Fournie-́Zaluski, and B. P. Roques. New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment. J. Med.Chem. 2014, Jul 10; 57(13):5748-63 (Pubmed link)

Thibault K, E. Bonnard, S. Dubacq, M.-C. Fournié-Zaluski, B.P. Roques, B. Calvino. Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine. Eur. J. Pharmacol. 2008, Dec 14;
600(1-3):71-77 (Pubmed link)

Inguimbert N., Coric P., Dhotel H., Bonnard E., llorens-Cortes C., Mota N., Fournié-Zaluski M.-C., Roques B.P. Synthesis and in vitro activities of new non-peptidic APA inhibitors. J. Pept. Res. 200565(2):175-188 (Pubmed link)

Bonnard E., Burlet-Schiltz O., Monsarrat B., Girard J.-P. and Zajac J.-M. Identification of proNeuropeptide FFA peptides processed in neuronal and non-neuronal cells and in nervous tissue. Eur. J. Biochem. 2003. 270:4187-4199 (Pubmed link)

Bonnard E., Mazarguil H. and Zajac J.-M. Peptide nucleic acids targeted to the mouse proNPFFA reveal an endogenous opioid tonus. Peptides 2002. Jun 23(6):1107-1113 (Pubmed link)

Bonnard E., Burlet-Schiltz O., Francés B., Mazarguil H., Monsarrat B., Zajac J.-M. and Roussin A. Identification of Neuropeptide FF-related peptides in rodent spinal cord. Peptides 2001. 22:1085-1092 (Pubmed link)

Bétuing S., Daviaud D., Pagès C., Bonnard E., Valet P., Lafontan M., Saulnier-Blache JS. Gindependent coupling of alpha2-adrenergic receptor to p21 (rhoA) in preadipocytes. J. Biol. Chem. 1998 Jun 19; 273 (25): 15804-15810 (Pubmed link)

Lozano V.C., Bonnard E, Gauthier M., Richard D. Mecamylamine-induced impairment of acquisition and retrieval of olfactory conditioning in the honeybee. Behav. Brain Res. 1996 (1-2): 215-222 (Pubmed link)


Biomarkers / Lipidomics

Lacoste E, Exploration of skin surface lipids in veterinary species, Proceedings European Association of Veterinary Pharmacology and Toxicology 2012 / Noordwijkerhout, The Netherlands (Poster link)

Lacoste E, Lipidomics for the research of surrogate biomarkers in milk from cows with sub-clinical mastitis: a pilot study, Proceedings European Association of Veterinary Pharmacology and Toxicology 2012 / Noordwijkerhout, The Netherlands (Poster link)

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