Imavita publications / Preclinical efficacy CRO
Scientific background & Publications of the scientific team of Imavita (Bibliography / Scientific Communications)


Dermatology preclinical efficacy Imavita

Dermatology

R. Jebbawi, A. Oukhrib, E. Clement, M. Blanzat, C-O. Turrin, A-M. Caminade, E. Lacoste , S. Fruchon, Rémy Poupot, An Anti-Inflammatory Poly(PhosphorHydrazone) Dendrimer Capped with AzaBisPhosphonate Groups to Treat Psoriasis. Biomolecules 10, 949 (2020).

E. Bonnard, T. Chamoux, M. Chusseau, V. Albinet, C. Antoine, E. Lacoste, Optimisation de l’expérimentation animale menée dans des modèles précliniques d’inflammation chronique de la peau chez la souris, par le développement d’une technique de Tomographie par Cohérence Optique (OCT), AFSTAL 2019 (poster) / STAL 4th Trim. 2019 (article)

A. Blanco, E. Lacoste, V. Albinet, A. Gavaldà, Murine models relevant to acne: Ear sebaceous gland and Rhino comedone models, January 2019, Journal of Comparative Pathology 166:120, DOI:10.1016/j.jcpa.2018.10.066 / Proceedings of the Joint 36th Congress of the European Society of Veterinary Pathology and 29th Congress of the European College of Veterinary Pathologists, Cluj-Napoca, Romania, 5th September – 8th September, 2018 (Poster link)

Lacoste E., Imagerie par Tomographie Optique Cohérente (OCT) in vivo chez l’animal de laboratoire : Corrélation avec l’histologie ex vivo, 31ème Congrès AFH (Association Française d’Histotechnologie), Toulouse, France, 21-22 juin 2018 (AFH 2018 program / Oral presentation available on request)

Lacoste E, Exploration of skin surface lipids in veterinary species, Proceedings European Association of Veterinary Pharmacology and Toxicology 2012 / Noordwijkerhout, The Netherlands (Poster link)


Oncology preclinical efficacy Imavita

Oncology

V. Albinet, E. Lacoste, R. Baron, R. Palmantier, M. Frohlich, J.L. Dasseux, Novel Apolipoprotein-A1 (ApoA-I) multimers, Cargomer®, as new targeted delivery platform for therapeutic cancer vaccines with tumor neo- and shared-antigens, Poster board PB-100, Abstract N°149, 30th EORTC-NCI-AACR SYMPOSIUM, Dublin, Ireland, 13-16 June 2018 (Abstract link / Poster PDF)

V. Albinet, E. Lacoste, R. Baron, R. Palmantier, M. Frohlich, J.L. Dasseux, Pre-beta HDL discoidal mimetic, CER-001®, and novel Apolipoprotein A-I (ApoA-I) multimers, Cargomer®, as new targeted delivery vehicles for therapeutic cancer medicines, Poster board PB-024, Abstract N°263, 30th EORTC-NCI-AACR SYMPOSIUM, Dublin, Ireland, 13-16 June 2018 (Abstract link / Poster PDF)

Poitevin S, Cussac D, Leroyer AS, Albinet V, Sarlon-Bartoli G, Guillet B, Hubert L, Andrieu-Abadie N, Couderc B, Parini A, Dignat-George F, Sabatier F, Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. Cardiovasc Res. 2014 Jul 1;103(1):121-30  (PubMed link)

Albinet V, Bats ML, Huwiler A, Rochaix P, Chevreau C, Ségui B, Levade T, Andrieu-Abadie N. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene. 2013 Jul 29 (PubMed link)

Albinet V, Bats ML, Bedia C, Sabourdy F, Garcia V, Ségui B, Andrieu-Abadie N, Hornemann T, Levade T. Genetic disorders of simple sphingolipid metabolism. Sphingolipids: Basic Science and Drug Development, Handbook of Experimental Pharmacology Volume 215, 2013, pp 127-152 (PubMed link)

Sorli SC, Colié S, Albinet V, Bedia C, Carpentier S, Ségui B, Guilbaud N, Levade T, Andrieu-Abadie N. Non-lysosomal beta-glucosidase GBA2 as a novel source of glucosylceramide catabolism involved in the regulation of melanoma growth. FASEB J. 2013 Feb;27(2):489-98 (PubMed link)

Albinet V, Bedia C, Huwiler A, Levade T, Andrieu-Abadie N, Role of sphingolipids in melanoma-stroma interactions, Bulletin du Cancer, Oct 2010, 97(4), S18-S18 (Poster link)

Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N. Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res. 2009 Dec 15;69(24):9346-53 (PubMed link)

Autefage H, Albinet V, Garcia V, Berges H, Nicolau ML, Therville N, Altié MF, Caillaud C, Levade T, Andrieu-Abadie N. Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner. J Biol Chem. 2009 Apr 24;284(17):11507-16 (PubMed link)

Decaup E, Rochotte J, Pyronnet S, Bousquet C. Focal Adhesion Kinase: A promising therapeutic target in pancreatic adenocarcinoma. Jean C. Clin Res Hepatol Gastroenterol. 2017 Jun;41(3):246-248. doi: 10.1016/j.clinre.2016.10.010. Epub 2016 Dec 6 (PubMed link)

Bertrand F, Rochotte J, Colacios C, Montfort A, Andrieu-Abadie N, Levade T, Benoist H, Ségui B, Targeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma? Oncoimmunology. 2015 Aug 12;5(1):e1068495. eCollection 2016 (PubMed link)

Bertrand F, Rochotte J, Colacios C, Montfort A, Tilkin-Mariamé AF, Touriol C, Rochaix P, Lajoie-Mazenc I, Andrieu-Abadie N, Levade T, Benoist H, Ségui B, Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma. Cancer Res. 2015 Jul 1;75(13):2619-28. doi: 10.1158/0008-5472.CAN-14-2524. Epub 2015 May 14 (PubMed link)


Preclinical imaging

Lacoste E, Dual energy computed tomography imaging of atherosclerosis in an induced focal aortic inflammation rabbit model, Proceedings European Atherosclerosis Society 2012 / 80th EAS Congress, Milan, Italy, May 25-28th 2012 (Poster link).
Lacoste E, Dual energy computed tomography imaging of atherosclerosis in a diet induced atheroma rabbit model, Proceedings European Atherosclerosis Society 2011 / 79th EAS Congress, Gothenburg, Sweden, June 26-29th 2011 (Poster link)


Pharmacokinetics / Pharmacodynamics

Kovalchin J, Krieger J, Collins K, Genova M, Augustyniak M, Masci A, Avril T, Gandon G, Patat A, Fauchoux N, Toutin C, Lacoste E, Patel U, Mascioli E, Zanelli E, Safety, pharmacokinetic, and pharmacodynamic evaluations of PI-2301, a potent immunomodulator, in a first-in-human, single-ascending-dose study in healthy volunteers. J Clin Pharmacol. 2011 May;51(5):649-60 (PubMed link).

DeLay RL, Lacoste E, Mezzasalma T, Blond-Riou F, Pharmacokinetics of metaflumizone and amitraz in the plasma and hair of dogs following topical application, Vet. Parasitol., 2007, 150 (3), 251-7 (PubMed link).

DeLay RL, Lacoste E, Delprat S, Blond-Riou F, Pharmacokinetics of metaflumizone and amitraz in the plasma and hair of cats following topical application, Vet. Parasitol., 2007, 150 (3), 258-62 (PubMed link)

Alvinerie M, Lacoste E, Sutra JF, Chartier C.Some pharmacokinetic parameters of eprinomectin in goats following pour-on administration, Vet Res Commun. 1999 Nov;23(7):449-55 (PubMed link).


Biomarkers / Lipidomics
Lacoste E, Exploration of skin surface lipids in veterinary species, Proceedings European Association of Veterinary Pharmacology and Toxicology 2012 / Noordwijkerhout, The Netherlands (Poster link)

Lacoste E, Lipidomics for the research of surrogate biomarkers in milk from cows with sub-clinical mastitis: a pilot study, Proceedings European Association of Veterinary Pharmacology and Toxicology 2012 / Noordwijkerhout, The Netherlands (Poster link)

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