Imavita / Preclinical imaging

Preclinical models in cardiovascular diseases

In the area of cardiovascular diseases, examples of preclinical models associated with quantitative imaging are shown below:

Myocardial infarction model in rodents

Cardiovascular models
  • LCA ligature model to induce Myocardial Infarctus (MI)
  • SPECT/CT imaging (99mTc sestamibi) with ECG gating
  • Telemetry  / ECG / blood pressure monitoring
  • Histology / macroscopic evaluation of lesions
  • Longitudinal study permitted with SPECT/CT imaging
  • Quantitative imaging biomarkers for myocardium viability / lesion extent

Atherosclerosis in rodents & non rodents

  • Transgenic rodent models ApoE or LDLR KO + feeding
  • Rabbit feeding (cholesterol chow)
  • Atheroma plaques imaging / longitudinal studies (SPECT/CT, FMT)
  • Histology / macroscopic evaluation of lesions
  • Quantitative imaging biomarkers of atherosclerosis

For additional informations on these models or on other preclinical models in the cardiovascular area, please inquire.