Oncology preclinical models
In vitro tests efficacy
- In vitro efficacy testing: Growth inhibition / Cytotoxicity activity
- Cytometry analysis / Non-adherent cells
- ALDH activity
- Specific stainings
Transplantation mouse models
- In-house in vitro facility
- Cells preparation / Cell line amplification
- Cells counting and control prior injection
- Primary tumour following SC / orthotopic implantation
- Metastasis dissemination following ortho. / IV / IP / IC injections
Syngeneic models / examples
- Breast adenocarcinoma: 4T1 / Balb/c mice
- Pancreascarcinoma: TGP49
- Melanoma: B16 & B16F10 / C57BL/6
Xenograft models / examples
- Acute Myeloid Leukemia / AML: MOLM-14 cell line
- Pancreas carcinoma: Mia-Pa-Ca / Panc-1 cell lines
- Breast adenocarcinoma: MDA-MB-231 cell line
- Melanoma: A375 cell line
- Lung carcinoma: A549 cell line
Tumour / Metastasis dissemination / in vivo evaluation
- Tumour volume / Caliper measurement
- Bioluminescence / Fluorescence Tomography (FMT)
- Ultrasound high & low resolution
- SPECT/CT (99mTc, 111In, 123I, 201Th / Dual detection possible)
- PET/CT (18F / FDG)
- Micro-angiography (terminal)
Tumour characterization / ex vivo
- Cytometry (AML)
- Histology / IHC / Histomorphometry
- Tumour morphology HES
- Vascularization / Angiogenesis / IHC CD31/CD34
- Leucocyte infiltration / IHC CD45
- Proliferation index / IHC Ki-67
For additional informations on these models or on other preclinical models in the oncology area, please inquire.