Oncology preclinical models

 

In vitro tests efficacy

Oncology preclinical efficacy Imavita

  • In vitro efficacy testing: Growth inhibition / Cytotoxicity activity
  • Cytometry analysis / Non-adherent cells
    • ALDH activity
    • Specific stainings

 

Transplantation mouse models

Preclinical model oncology Imavita

  • In-house in vitro facility
    • Cells preparation / Cell line amplification
    • Cells counting and control prior injection
  • Primary tumour following SC / orthotopic implantation
  • Metastasis dissemination following ortho. / IV / IP / IC injections

Syngeneic models / examples

  • Breast adenocarcinoma: 4T1 / Balb/c mice
  • Pancreascarcinoma: TGP49
  • Melanoma: B16 & B16F10 / C57BL/6

Xenograft models / examples

  • Acute Myeloid Leukemia / AML: MOLM-14 cell line
  • Pancreas carcinoma: Mia-Pa-Ca / Panc-1 cell lines
  • Breast adenocarcinoma: MDA-MB-231 cell line
  • Melanoma: A375 cell line
  • Lung carcinoma: A549 cell line

 

Tumour / Metastasis dissemination / in vivo evaluation

Preclinical imaging Oncology Imavita

  • Tumour volume / Caliper measurement
  • Bioluminescence / Fluorescence Tomography (FMT)
  • Ultrasound high & low resolution
  • SPECT/CT  (99mTc, 111In, 123I, 201Th / Dual detection possible)
  • PET/CT (18F / FDG)
  • Micro-angiography (terminal)

 

Tumour characterization / ex vivo

  • Cytometry (AML)Preclinical efficacy in vitro ALDH
  • Histology / IHC / Histomorphometry
  • Tumour morphology HES
  • Vascularization / Angiogenesis / IHC CD31/CD34
  • Leucocyte infiltration / IHC CD45
  • Proliferation index / IHC Ki-67

For additional informations on these models or on other preclinical models in the oncology area, please inquire.

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