Imavita is proud to announce a new team member with the recent recruitment of Claire Coustal.
Claire Coustal, Apprentice MSc, Research Scientist Assistant. Claire is actually graduating Master 2 (M2) Innovating Drug therapies and Biotherapeutics (“Biothérapies et Médicaments de Thérapie Innovante”) from University of Nantes, France. Claire works now at Imavita in the in vitro lab and in vivo models for drug efficacy evaluation principally in the field of Osteo-Articular disease and Neurology/Neuro-Inflammation.
IMAVITA S.A.S., an innovating technology company providing services in preclinical models of human pathologies associated with imaging and image analysis, announces its participation in the collaborative project PICSTEM.
This 2-years project will focus on the fields of osteo-articular diseases (Psoriatic Arthritis, Osteo-Arthritis and Ankylosing Spondyloarthritis) and neurology (neuro-inflammation in Recurrent-Remittent Multiple Sclerosis and Sciatic nerve inflammation).
IMAVITA will actively participate in this project by providing technical and scientific expertise and relevant preclinical models of human pathologies. This project will allow IMAVITA to develop new animal models and develop new translational services in preclinical and clinical imaging.
Imavita is proud to announce New Team members with the recent recruitment of Maud Chusseau and Julia Rochotte.
Maud Chusseau, MSc, Research Scientist, Maud is graduated from University of Lyon, France (Master Pharmacology / Animal experimentation 2007). Maud has several industry experiences (SeleXel, Endotis Pharma, Galapagos, Servier). Maud works now at Imavita in the in vitro lab and in vivo models for drug efficacy evaluation and has experience in qPCR, animals surgery and small animal imaging.
Julia Rochotte, PhD, Immunologist, Project Leader, Julia is a young PhD graduated on 2014. She has spent 7 years at the laboratory of the Center of Oncology Research of Toulouse (Centre de Recherche en Cancérologie de Toulouse (CRCT) U1037 INSERM / UPS / CNRS) with an important background in immunology and immuno-oncology.
This 3-year project will focus on the fields of oncology, cardiovascular and neurology, for which 4 work teams have been created:
Synthesis, purification and structural analysis of radiolabelling precursors with Fluor 18 and development of various syntheses of radio-fluorinated molecules,
Production of radiolabelled molecules for injection in pre-clinical models,
Development and implementation of animal pathological models, PET/CT imaging and quantitative analysis of imaging data for therapeutic targeting validation,
Production in pharmaceutical quality and use of radiolabelled products in clinical trials
IMAVITA will actively participate in this project by providing technical and scientific expertise and relevant preclinical models of cancer, atherosclerosis and Alzheimer’s disease.
This project will allow IMAVITA to develop new animal models, access custom and innovative radio tagging skills, explore existing preclinical models in PET/CT imaging and develop new translational services in preclinical and clinical imaging.
Ce projet de 3 ans sera axé dans les domaines de l’oncologie, cardio-vasculaire et neurologie et pour lesquels 4 équipes de travail ont été créées :
1/ Synthèse, purification et analyse structurale de précurseurs de radio-marquage avec le Fluor 18 et mise au point des diverses synthèses de molécules radio-fluorées,
2/ Production des molécules radio-marquées pour injection dans des modèles pré-cliniques,
3/ Développement et mise en place des modèles animaux pathologiques, imagerie PET/CT et analyse quantitative des données d’imagerie pour validation du ciblage thérapeutique,
4/ Production en qualité pharmaceutique et utilisation des productions de produits radio-marqués dans le cadre d’essais cliniques
La société IMAVITA participera activement à ce projet par la mise à disposition de compétences techniques et scientifiques et la fourniture de modèles précliniques pertinents de cancer, d’athérosclérose et de maladie d’Alzheimer.
Ce projet permettra à IMAVITA le développement de nouveaux modèles animaux, l’accès à des compétences de radio-marquage à façon et innovants, l’exploration en imagerie PET/CT de modèles précliniques existants et de nouveaux services translationnels en imagerie préclinique et clinique.
This imaging technique is available for in vivo (isofluran anesthesia) and/or ex vivo imaging and permits to accelerate evaluation of efficacy of compounds during course of projects or on sample collection.
Image example (atopic dermatitis model / ear):
Imavita developed a quantification algorithm to permit measurement of epidermis thickness immediatley after image capture. Correlation and validation of this imaging biomarker was fully performed in comparison to histology.
Release of in vivo OCT imaging in preclinical models was performed on November 2018.
Imavita is proud to announce the acquisition of new Optical Coherence Tomography apparatus to develop Innovating imaging of dermatology models.
Since september 2017, Imavita is working on this innovative imaging system (OQ Labscope / Lumedica) which will permit to generate non-invasive, surface tissue quantitative data for pre-clinical models in place at Imavita in Applications of interest, principally in the area of dermatology.
The benefits of this in vivo imaging modality are:
Easily and efficiently obtain calibrated quantitative data in preclinical models
Deepen understanding of disease mechanisms, disease progression and therapeutic responses
Manage costs and capture time course data by avoiding sacrifice of animal models
For more informations, do not hesitate to contact us.
