Pathology background

Acne models ImavitaAcne is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. The resulting appearance may lead to anxiety, reduced self-esteem, and in extreme cases, depression or thoughts of suicide.
That’s the reason why preclinical models of acne are needed for testing efficacy prior to clinical testing.
These models include hamster and mouse preclinical models.
IMAVITA is able now to propose operational efficacy testing service in this pathology.

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Rhino Mouse Acne Model ImavitaAcne preclinical model / Rhino mouse model

Rhino mouse strain RHJ/LeJ

Application of dermatological products (topical / Medical Devices)

Evaluation of skin thickness and skin macroscopic description

In vivo imaging using OCT

Ex vivo imaging

– Histology HES on serial slices
– 3D reconstruction of sebaceous glands for volume evaluation
– Immunohistochemistry
– MALDI imaging

More informations on specific page Rhino mouse model

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Acne preclinical model / Hamster flank organ model

Mature male hamster

Application of dermatological products (topical) / Medical Devices Acne preclinical models

Evaluation of:

– Flank organ size using caliper (width / length / surface)
– Flank organ coloration & macroscopic description

In vivo imaging:Acne preclinical models

– OCT
– Ultrasonography for flank organ thickness evaluation

Ex vivo imaging:

– Histology / Immunohistochemistry
– MALDI imaging (in collaboration)

More informations on specific page Hamster fank organ model

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Acne preclinical model / P. acnes (Cutibacterium) infection model

P.acnes (Cutibacterium) injection in normal mouse ear

Evaluation of ear inflammation in vivo / ex vivo

– in vivo: Ear calipering / OCT imaging

CIR _ Research Tax Credit Imavita

– ex vivo: HES histology

This model is on development actually, please contact us for more information

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