Pathology background
Acne is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. The resulting appearance may lead to anxiety, reduced self-esteem, and in extreme cases, depression or thoughts of suicide.
That’s the reason why preclinical models of acne are needed for testing efficacy prior to clinical testing.
These models include hamster and mouse preclinical models.
IMAVITA is able now to propose operational efficacy testing service in this pathology.
Acne preclinical model / Rhino mouse model
- Rhino mouse RHJ/LeJ
- Application of dermatological products (topical) / Medical Devices
- Evaluation of:
- Skin thickness using caliper
- Skin macroscopic description
- Ex vivo imaging
- Histology HES on serial slices
- 3D recontsruction of sebaceous glands for volume evaluation
- Immunohistochemistry
- MALDI imaging (in collaboration)
Acne preclinical model / Hamster flank organ model
- Mature male hamster
- Application of dermatological products (topical) / Medical Devices
Acne preclinical models
- Evaluation of:
- Flank organ size using caliper (width / length / surface)
- Flank organ coloration & macroscopic description
- In vivo imaging:
- Ultrasonography for flank organ thickness evaluation
- Ex vivo imaging
- Histology HES on serial slices
- 3D recontsruction of sebaceous glands for volume evaluation
- Immunohistochemistry
- MALDI imaging (in collaboration)