Pathology background

Acne models Imavita

Acne is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. The resulting appearance may lead to anxiety, reduced self-esteem, and in extreme cases, depression or thoughts of suicide.
That’s the reason why preclinical models of acne are needed for testing efficacy prior to clinical testing.
These models include mice and hamster preclinical models.
IMAVITA is able now to propose operational efficacy testing service in this pathology.—-

P. acnes (Cutibacterium) Infection Acne Model

P.acnes (Cutibacterium) injection in normal mouse ear

Evaluation of ear inflammation biomarkers in vivo / ex vivo
– in vivo: Ear calipering / OCT imaging
– ex vivo: Genes expression qPCR / Cytokines analysis / HES histology

More informations on specific page C.acnes model


Acne preclinical models

Hamster Flank Organ Acne Model

Mature male hamster
Application of dermatological products

Evaluation of:
– Flank organ size using caliper (width / length / surface)
– Flank organ coloration & macroscopic description

In vivo imaging:
– Ultrasonography for flank organ thickness evaluation

Ex vivo imaging:
– Histology / Immunohistochemistry
– MALDI imaging (in collaboration)

More informations on specific page Hamster flank organ model



Rhino Mouse Acne Model

Rhino mouse strain RHJ/LeJ
Application of dermatological products
Evaluation of skin thickness and skin macroscopic description

In vivo imaging using OCT

Ex vivo imaging:
– Histology HES on serial slices
– Immunohistochemistry
– MALDI imaging

More informations on specific page Rhino mouse model