Pathology background
Acne is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. The resulting appearance may lead to anxiety, reduced self-esteem, and in extreme cases, depression or thoughts of suicide.
That’s the reason why preclinical models of acne are needed for testing efficacy prior to clinical testing.
These models include mice and hamster preclinical models.
IMAVITA is able now to propose operational efficacy testing service in this pathology.—-
P. acnes (Cutibacterium) Infection Acne Model
P.acnes (Cutibacterium) injection in normal mouse ear
Evaluation of ear inflammation biomarkers in vivo / ex vivo
– in vivo: Ear calipering / OCT imaging
– ex vivo: Genes expression qPCR / Cytokines analysis / HES histology
More informations on specific page C.acnes model
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Hamster Flank Organ Acne Model
Mature male hamster
Application of dermatological products
Evaluation of:
– Flank organ size using caliper (width / length / surface)
– Flank organ coloration & macroscopic description
In vivo imaging:
– OCT
– Ultrasonography for flank organ thickness evaluation
Ex vivo imaging:
– Histology / Immunohistochemistry
– MALDI imaging (in collaboration)
More informations on specific page Hamster flank organ model
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Rhino Mouse Acne Model
Rhino mouse strain RHJ/LeJ
Application of dermatological products
Evaluation of skin thickness and skin macroscopic description
In vivo imaging using OCT
Ex vivo imaging:
– Histology HES on serial slices
– Immunohistochemistry
– MALDI imaging
More informations on specific page Rhino mouse model