Atopic Dermatitis model IL23

IL23-induced AD preclinical model

• Repeated intradermal injection of rIL23 in ear
• Immunocompetent rodent sp.  (C57Bl6 strain)
• Clinical endpoints / scoring (equivalent to SCORAD):
  • Back skin dryness/scaling
  • Back skin redness/erythema
  • Ear and back skin thickness/edema
  • Back skin excoriations
  • Itching (observed behaviour)
• Ethical endpoints: bodyweight / feeding & drinking behavior / general behavior / maximal scoring threshold
• Skin biomarkers analysis
• Ex vivo imaging (histology HES / IHC)
• Statistical analysis of efficacy data: clinical scoring and histomorphometrics