Preclinical services in neurology domain
Neuro-inflammation
Multiple Sclerosis in vivo Models
Chronic Sclerosis model / EAE MOG/CFA
- Chronic EAE in C57Bl6 mice
- Auto-immunization with peptide MOG35-55 (or MOG1-125) + FA
- Positive control / Dexamethasone or FTY720
- In vivo evaluation
Daily scoring (0 to 5 based on behavior / tail and hindlimb) - In vivo imaging
FRI or FMT imaging / BBB damage or macrophage infiltration
MRI imaging / BBB damage
Relapsing-Remitting Sclerosis model / EAE PLP/CFA
- Relapsing-remiting EAE in SJL mice
• Auto-immunization with peptide PLP 139-151 + FA - In vivo evaluation
Daily scoring (0 to 5 based on behavior / tail and hindlimb) - In vivo imaging
FRI or FMT imaging / BBB damage or macrophage infiltration
MRI imaging / BBB damage
Itching models
- Complementary to Atopic Dermatitis models
- Intra-dermal injection with different inducers:
Histamine / Serotonin (5HT) / SLIGRL-NH2 peptide / Substance P / Chloroquin
Sterile saline as vehicle - Treatment with drugs prior to ID inductors (-2h to -30min)
- Video recording in observation cages / Manual counting of itching bouts