Imavita can evaluate drug disposition and pharmacokinetics (PK) of drugs in preclinical models using unlabeled compound (classical approach) or & using labeled compounds (in vivo imaging approach).
This approach can be applied to:
- Evaluation of basic pharmacokinetics parameters (F, Vd, T1/2, Cl, etc…) of a molecule
- Selection of molecules based on biodistribution and tissue target
- Targeting / optimization of galenic formulations
- Toxicology studies validation by the evaluation of exposition
Pharmacokinetics / early PK / Biodistribution / Elimination evaluation / ADME
- Terminal sampling with blood and tissue collection
- Serial blood sampling from catheterized veins (jugular and/or femoral veins)
- Evaluation of drug PK / ADME / biodistribution
- Tissue analysis on collected tissues and matrices by MS analysis (LCMS / MALDI or LAESI on tissue slices (in collaboration))
- in vivo imaging and image analysis
- SPECT/CT (99mTc, 111In, 201Tl, 123I labels)
- MRI (Gd label)
- Biodistribution / PK parameters calculations (F, Vd, T1/2, Cl, etc…)
Pharmacodynamics / PK/PD relationships
- Blood / Bile / lymph / CSF catheterized rats
- Objectives:
- Transport evaluation of molecules
- PK/PD relationships
Samples storage facility (-20°C / -80°C / liquid nitrogen)