Alopecia preclinical models / Pathology background / Clinical views

Alopecia preclinical models are necessary in R&D.
The medical term for the loss of hair on the head or body is alopecia.
Alopecia can take many different forms, but the most prevalent ones are alopecia areata and androgenic alopecia.
Alopecia is not a fatal condition, but it can have a significant psychological impact on those who have it and change their lives.

Hair loss from small, patchy bald spots to total loss of scalp or body hair is a defining feature of alopecia areata, a complex inflammatory illness. Although it can impact people of any age or gender, it typically shows up in childhood or early adulthood. The most popular treatments for alopecia include topical medications, which are intended to promote hair growth and control the immune system. Relapse is frequent, though, and the effectiveness of various treatments varies greatly.
Alopecia affects about 2% of people worldwide, making it a serious global health concern due to its unpredictable course and profound psychological effects.
In androgenetic (or pattern) alopecia, terminal hairs gradually turn into indeterminate and then vellus hairs, a genetically determined condition. The illness is quite widespread and can afflict both men and women.
Alopecia preclinical models were developed as models of alopecia androgenetic or areata.

In clinical oncology, chemotherapy-induced alopecia (ChIA) is still an open issue. Psycho-social stress is brought on by hair loss, and some patients will even decline treatment out of concern for their hair.
Regrowth can be seen 3–6 months after chemotherapy ends, and ChIA is typically reversible. However, there have been more and more reports of permanent ChIA, which is defined as no hair growth after six months of stopping chemotherapy. The underlying patho-physiology, particularly for permanent ChIA, remains insufficiently understood and is associated with a lack of effective preventive treatment.

Alopecia preclinical models were developed at Imavita for R&D purpose.

Models Overview

Alopecia aerata / Androgenetic alopecia / Hair regrowth model

Alopecia preclinical models
Simple hair regrowth model on aged animals and/or shaving induction
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Chemotherapy induced alopecia model

Alopecia preclinical models
Hair regrowth model after chemotherapy (cyclophosphamide) alopecia induction
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