Ex vivo preclinical CRO for advanced research
Imavita is a specialized ex vivo preclinical CRO, which offers innovative solutions to support drug discovery and development. Ex vivo models maintain the native tissue environment, enabling high-resolution insights into drug responses and biomarker evaluations. These services provide pharmaceutical companies, biotech firms, and research laboratories with reliable tools to explore complex cellular and molecular mechanisms.
Choosing ex vivo models for preclinical research
Preserve tissue architecture and functionality
Ex vivo models retain the natural structure and functionality of tissues, providing more accurate insights into drug interactions.
Complement in vivo and in vitro research
They serve as a critical step between in vitro screening and in vivo studies, enhancing the predictive power of preclinical evaluations.
Ethical and sustainable research
By maximizing the data obtained from tissue samples, ex vivo studies reduce animal usage, aligning with ethical research practices and 3Rs rules.
The expertise of Imavita in ex vivo models
Tissue-based models for advanced insights
Organ Cultures: Maintain tissue-specific architecture to study localized drug effects.
Slice Cultures: Explore cellular responses while preserving microenvironment interactions.
Perfused Organ Systems: Assess drug disposition and metabolism in isolated organs under controlled conditions.
Explants: Preserve tissue integrity and microenvironment, enabling physiologically relevant drug response assessment.
Slice Cultures: Explore cellular responses while preserving microenvironment interactions.
Perfused Organ Systems: Assess drug disposition and metabolism in isolated organs under controlled conditions.
Explants: Preserve tissue integrity and microenvironment, enabling physiologically relevant drug response assessment.
Biomarker evaluation and quantification
Precise analysis of imaging biomarkers from ex vivo models using advanced techniques.
Assessment of drug-target interactions and therapeutic responses by quantifying the expression of molecular markers.
Assessment of drug-target interactions and therapeutic responses by quantifying the expression of molecular markers.
Application across different therapeutic areas
Our ex vivo models are tailored for various research areas.
Dermatology
Wound healing, psoriasis, and atopic dermatitis.
Oncology
Tumor microenvironment studies and drug efficacy validation.
Osteo-Articular
Bone healing and cartilage regeneration.
Neurology
Under develoment.
Advanced imaging techniques applied to ex vivo models
To complement and validate in vivo imaging, Imavita performs the following ex vivo imaging modalities:
Micro-CT: High-resolution imaging of tissue structure.
Histology and Optical Microscopy: Detailed cellular analysis with fluorescence or classical staining techniques.
MALDI/MS Imaging in partnership: Molecular imaging to map drug distribution.
Confocal and Electron Microscopy (SEM): Explore ultra-structural details of tissues.
Micro-CT: High-resolution imaging of tissue structure.
Histology and Optical Microscopy: Detailed cellular analysis with fluorescence or classical staining techniques.
MALDI/MS Imaging in partnership: Molecular imaging to map drug distribution.
Confocal and Electron Microscopy (SEM): Explore ultra-structural details of tissues.
Why partner with Imavita as your ex vivo preclinical CRO
Tailored models for specific research needs
Customizable ex vivo platforms designed to address your unique research objectives.
Use of ethical and responsible practices
Rigorous application of ethical principles to reduce animal usage while maximizing data output.
Advanced technologies
Access to advanced imaging modalities and expertise in quantitative analysis.
Proven expertise across different therapeutic areas
Extensive experience in dermatology, oncology, and osteo-articular, and also a strong adaptability in physiopathology.
Enhance your preclinical research with Imavita’s tailored ex vivo models.
FAQ
What are ex vivo models?
Ex vivo models allow the study of tissues or organs outside the living organism while maintaining their natural structure and functionality. These models provide high-resolution insights into drug responses and biomarker modulation.
How do ex vivo models complement in vivo studies?
What imaging techniques are used in ex vivo studies?
