Drug disposition / PK

Imavita can evaluate drug disposition and pharmacokinetics (PK) of drugs in preclinical models using unlabeled compound (classical approach) or & using labeled compounds (in vivo imaging approach).
This approach can be applied to:

• Evaluation of basic pharmacokinetics parameters (F, V_d, T_1/2, Cl, etc…) of a molecule
• Selection of molecules based on biodistribution and tissue target
• Targeting / optimization of galenic formulations
• Toxicology studies validation by the evaluation of exposition

Pharmacokinetics / early PK / Biodistribution / Elimination evaluation / ADME

• Terminal sampling with blood and tissue collection
• Serial blood sampling from catheterized veins (jugular and/or femoral veins)
• Evaluation of drug PK / ADME / biodistribution
  • Tissue analysis on collected tissues and matrices by MS analysis (LCMS / MALDI or LAESI on tissue slices (in collaboration))
  • in vivo imaging and image analysis
• SPECT/CT (^99mTc, ¹¹¹In, ²⁰¹Tl, ¹²³I labels)
• MRI (Gd label)
• Biodistribution / PK parameters calculations (F, V_d, T_1/2, Cl, etc…)

Pharmacodynamics / PK/PD relationships

• Blood / Bile / lymph / CSF catheterized rats
• Objectives:
  • Transport evaluation of molecules
  • PK/PD relationships

Samples storage facility (-20°C / -80°C / liquid nitrogen)