• Hapten model induction
• Sensitization and repeated challenge with oxazolone / topically on back and ear
• Immunocompetent rodent sp. (Balb/c strain)
• Clinical endpoints / scoring (equivalent to SCORAD):
  • Back skin dryness/scaling
  • Back skin redness/erythema
  • Ear and back skin thickness/edema
  • Back skin excoriations
  • Itching (observed behaviour)
• Ethical endpoints: bodyweight / feeding & drinking behavior / general behavior / maximal scoring threshold
• Corticoid (betamethasone, clobetasol) or immunosuppressor as positive control
• Blood samplings for circulating (cytokines)
• Skin biomarkers analysis
• Ex vivo imaging (histology HES / IHC / electron microscopy (SEM))
• Statistical analysis of efficacy data: clinical scoring and histomorphometrics

Induction with other chemicals for haptens induction (calcipotriol / DNCB) is also available

Please inquire for more details on Oxazolone induced Atopic Dermatitis Model