Imavita / Preclinical modelsImavita proposes preclinical models which can be used alone or associated with imaging modalities to permit the evaluation of efficacy of new compounds / new therapeutics treatments in development phase.

Species / strains

  • Rodents (rat / mouse / hamster / Guinea pig)
  • Non rodents (rabbits)

Healthy / normal models

  • Type of studies
    • Pharmacokinetics / early PK
    • Pharmacodynamics / PK/PD relationships
    • Biodistribution / Elimination evaluation
  • Example of projects
    • PK / early PK / PK/PD with serial or terminal sampling animals (in-life phase)
    • PK on catheterized animals (jugular / femoral / combined) for PK and/or PK/PD studies (in-life phase)
    • Bile / lymph / cerebrospinal fluid catheterized rats for pharmacokinetics evaluation / transport evaluation of molecules / PK/PD relationships (in-life phase)

Pathological models / induced pathologies

  • Type of studies
    • Evaluation of pharmacokinetics on pathological animals / impact of pathology on PK parameters
    • Efficacy studies with different approaches:
      • Classical approach / parallel groups
      • Longitudinal study (repeated measure experiment) by applying imaging modalities
  • Example of projects

Resources

  • Access to conventional facilities / SPF / SOPF for rodents
  • Access to conventional facilities for large species
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