Wound healing background / Clinical views

Wound healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers. The human adult wound healing process can be divided into 3 phases: inflammatory, fibroblastic  and remodeling.

Wound healing preclinical model / Imavita

Primary healing, delayed primary healing, and healing by secondary intention are the 3 main categories of wound healing.

Given the lack of efficacy and cost-effectiveness, there has been a lot of interest in new technologies that can improve wound care like nanotechnologies, biological drugs, mesenchymal stem cells, etc…

That’s the reason why preclinical models of skin wound healing are needed for testing efficacy prior to clinical testing.
IMAVITA is able now to propose operational efficacy testing service in this area.

Wound healing preclinical models / Overview

 

Induced wounds (thermal / mechanical / chemical induction) in rodents (diabetic / non diabetic) & large animals

 

Healing in ischemia / neuroishemia conditions

 

Evaluation of:

Clinical macroscopic endpoints
Macroscopic observations of wounds
Measurements of healing process (caliper): Wound diameter / surface, epithelialization diameter and dermal edge diameter migration
Protocol defined scoring

 

In vivo imaging

Calibrated photographs / pictures of wounds
Skin surface temperature using FLIR cameras for ischemia conditions control

 

Skin samplings for:

Histopathology / Histomorphometry
Immunohistochemistry
Biomarkers analysis (inflammation markers)

 

Image analysis for in vivo or ex vivo imaging biomarkers quantification

 

Statistical analysis of efficacy data

 

On-going R&DR&D Imavita

Development of non invasive imaging evaluation for longitudinal studies (Fluorescence Tomography / Optical Tomography)

 

 

 

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