Preclinical models in cardiovascular diseases
In the area of cardiovascular diseases, examples of preclinical models associated with quantitative imaging are shown below:
Myocardial infarction model in rodents
- LCA ligature model to induce Myocardial Infarctus (MI)
- SPECT/CT imaging (99mTc sestamibi) with ECG gating
- Telemetry / ECG / blood pressure monitoring
- Histology / macroscopic evaluation of lesions
- Longitudinal study permitted with SPECT/CT imaging
- Quantitative imaging biomarkers for myocardium viability / lesion extent
Atherosclerosis in rodents & non rodents
- Transgenic rodent models ApoE or LDLR KO + feeding
- Rabbit feeding (cholesterol chow)
- Atheroma plaques imaging / longitudinal studies (SPECT/CT, FMT)
- Histology / macroscopic evaluation of lesions
- Quantitative imaging biomarkers of atherosclerosis
For additional informations on these models or on other preclinical models in the cardiovascular area, please inquire.