Imavita proposes preclinical models which can be used alone or associated with imaging modalities to permit the evaluation of efficacy of new compounds / new therapeutics treatments in development phase.

Species / strains

• Rodents (rat / mouse / hamster / Guinea pig)
• Non rodents (rabbits)

Healthy / normal models

• Type of studies
  • Pharmacokinetics / early PK
  • Pharmacodynamics / PK/PD relationships
  • Biodistribution / Elimination evaluation
• Example of projects
  • PK / early PK / PK/PD with serial or terminal sampling animals (in-life phase)
  • PK on catheterized animals (jugular / femoral / combined) for PK and/or PK/PD studies (in-life phase)
  • Bile / lymph / cerebrospinal fluid catheterized rats for pharmacokinetics evaluation / transport evaluation of molecules / PK/PD relationships (in-life phase)

Pathological models / induced pathologies

• Type of studies
  • Evaluation of pharmacokinetics on pathological animals / impact of pathology on PK parameters
  • Efficacy studies with different approaches:
    • Classical approach / parallel groups
    • Longitudinal study (repeated measure experiment) by applying imaging modalities
• Example of projects
  • Efficacy of new molecules on skin healing (wound models) (See Dermatology applications)
  • Efficacy of new molecules on in Psoriasis & Atopic Dermatitis  (See Dermatology applications)
  • Efficacy studies in myocardial infarction induced rat (see Cardiovascular applications)
  • Efficacy of new molecules on bone healing in normal & osteoporosis rat model (see Osteoarticular applications)

Resources

• Access to conventional facilities / SPF / SOPF for rodents
• Access to conventional facilities for large species